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Trichinellosis is a worldwide important food-borne zoonosis caused mainly by ingesting raw or undercooked pork infected with  Trichinella spiralis  larvae. The development of vaccine is needed for preventing swine from  Trichinella  infection to ensure pork safety. Previous studies showed that  T. spiralis  serine protease 1.2 (TsSP1.2) is a vaccine candidate against  Trichinella  infection. In this study, the complete TsSP1.2 cDNA sequences were cloned into pcDNA3.1, and the rTsSP1.2 DNA was transformed into attenuated  Salmonella typhimurium  strain ΔcyaSL1344. Oral vaccination of mice with  Salmonella -delivered rTsSP1.2 DNA vaccine induced an obvious intestinal mucosal IgA response and a systemic Th1/Th2 immune response; the vaccinated mice showed a 33.45% reduction of intestinal adult worms and 71.84% reduction of muscle larvae after  T. spiralis  larval challenge. The protection might be due to the rTsSP1.2-induced production of specific anti-TsSP1.2 sIgA, IgG, IgG1/IgG2a, and secretion of IFN-γ, IL-4 and IL-10, which protected intestinal mucosa from the parasite invasion, inhibited worm development and reduced female fecundity. The results indicate that the attenuated  Salmonella -delivered rTsSP1.2 DNA vaccine offers a prospective strategy for the prevention and control of animal  Trichinella  infection.   Electronic supplementary material  The online version of this article (10.1186/s13567-018-0582-2) contains supplementary material, which is available to authorized users.

Protective immunity against Trichinella spiralis in mice elicited by oral vaccination with attenuated Salmonella-delivered TsSP1.2 DNA