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The minimum inhibitory concentration of bambermycin on three porcine  Helicobacter suis  strains was shown to be 8 μg/mL. The effect of in-feed medication with this antibiotic on the course of a gastric infection with one of these strains, the host response and the gastric microbiota was determined in mice, as all of these parameters may be involved in gastric pathology. In  H. suis  infected mice which were not treated with bambermycin, an increased number of infiltrating B-cells, T-cells and macrophages in combination with a Th2 response was demonstrated, as well as a decreased parietal cell mass. Compared to this non-treated, infected group, in  H. suis  infected mice medicated with bambermycin, gastric  H. suis  colonization was not altered, but a decreased number of infiltrating T-cells, B-cells and macrophages as well as downregulated expressions of IL-1β, IL-8M, IL-10 and IFN-γ were demonstrated and the parietal cell mass was not affected. In bambermycin treated mice that were not infected with  H. suis , the number of infiltrating T-cells and expression of IL-1β were lower than in non-infected mice that did not receive bambermycin. Gastric microbiota analysis indicated that the relative abundance of bacteria that might exert unfavorable effects on the host was decreased during bambermycin supplementation. In conclusion, bambermycin did not affect  H. suis  colonization, but decreased gastric inflammation and inhibited the effects of a  H. suis  infection on parietal cell loss. Not only direct interaction of  H. suis  with parietal cells, but also inflammation may play a role in death of these gastric acid producing cells.   Electronic supplementary material  The online version of this article (10.1186/s13567-018-0530-1) contains supplementary material, which is available to authorized users.

veterinary research

In-feed bambermycin medication induces anti-inflammatory effects and prevents parietal cell loss without influencing Helicobacter suis colonization in the stomach of mice