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Campylobacter  infections are among the most prevalent foodborne infections in humans, resulting in a massive disease burden worldwide. Broilers have been identified as the major source of campylobacteriosis and reducing  Campylobacter  loads in the broiler caeca has been proposed as an effective measure to decrease the number of infections in humans. Failure of current methods to control  Campylobacter  in broilers stresses the urgency to develop novel mitigation measures. We obtained six nanobodies with a broad specificity, that recognize strains belonging to the two most relevant species,  Campylobacter jejuni  and  Campylobacter coli . The target of the nanobodies was identified as the major outer membrane protein, a porin that contributes to bacterial virulence and viability. Multimerization of the nanobodies led to agglutination of  C. jejuni  cells, which may affect colonization in the chicken gut. These  Campylobacter -specific nanobodies may be useful to develop a strategy for preserving chickens from  Campylobacter  colonization.   Electronic supplementary material  The online version of this article (10.1186/s13567-017-0491-9) contains supplementary material, which is available to authorized users.

veterinary research

Nanobodies targeting conserved epitopes on the major outer membrane protein of Campylobacter as potential tools for control of Campylobacter colonization