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Swine dysentery caused by  Brachyspira hyodysenteriae , results in substantial economic losses in swine producing countries worldwide. Although a number of different vaccine approaches have been explored with regard to this disease, they show limitations and none of them have reached the market. We here determine the vaccine potential of a weakly haemolytic  B. hyodysenteriae  strain. The virulence of this strain was assessed in experimental infection trials and its protection against swine dysentery was quantified in a vaccination-challenge experiment using a seeder infection model. Systemic IgG production and local IgA production were monitored in serum and faeces respectively. Across all trials, pigs that were colonized by virulent, strongly haemolytic  B. hyodysenteriae  strains consistently developed swine dysentery, in contrast to none of the pigs colonized by the weakly haemolytic  B. hyodysenteriae  vaccine strain. In the seeder vaccination trial nearly all immunised animals developed swine dysentery on subsequent challenge with a virulent strain, but the speed of spread of swine dysentery and faecal score were significantly reduced in animals immunised with the weakly haemolytic strain compared to sham-immunised animals. The IgA response of immunised animals upon challenge with a virulent  B. hyodysenteriae  strain significantly correlated to a later onset of disease. The correlation between local IgA production and protection induced by a weakly haemolytic  B. hyodysenteriae  strain provides leads for future vaccine development against swine dysentery.

An avirulent Brachyspira hyodysenteriae strain elicits intestinal IgA and slows down spread of swine dysentery