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Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrP Sc  phenotypes were present: G 338  or Apl 338 ii. Thirteen months later some divergent PrP Sc  phenotypes were seen: a mixture of Apl 338 ii with either G 338  or P 338,  and a completely novel PrP Sc  deposition, designated Cag 338 . The data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant PrP Sc  biological/biochemical properties.

Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time