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Rationale  Evaluation of the feasibility of [ 18 F]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting.    Methods  Fifteen patients with a suspected malignant ovarian tumor were scanned with [ 18 F]EF5 and [ 18 F]FDG-PET/CT preoperatively. The distribution of [ 18 F]EF5-uptake, total intraabdominal metabolic tumor volume (TMTV), and hypoxic subvolume (HSV) were assessed.    Results  [ 18 F]EF5-PET/CT suggested hypoxia in 47% (7/15) patients. The median HSV was 87 cm 3  (31% of TMTV). The [ 18 F]EF5-uptake was detected in primary tumors and in four patients also in intra-abdominal metastases. The [ 18 F]EF5-uptake in cancer tissue was low compared to physiological excretory pathways, complicating the interpretation of PET/CT images.    Conclusions  [ 18 F]EF5-PET/CT is not feasible in ovarian cancer imaging in clinical setting due to physiological intra-abdominal [ 18 F]EF5-accumulation. However, it may be useful when used complementarily to FDG-PET/CT.

The feasibility of [18F]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study