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The aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normalized by patient’s weight in  68 Ga-PSMA11 PET/CT.    Material and methods   68 Ga-PSMA11 PET/CT scans of 121 patients with prostate cancer from two institutions were evaluated. Liver SUV was measured within a 3-cm volume-of-interest (VOI) in the right hepatic lobe and corrected for lean body mass using the Janmahasatian formula. SUV and SUL repeatability between baseline and follow-up scans of the same patients were assessed.    Results  SUV was significantly positively correlated with body weight ( r  = 0.35,  p  = 0.02). In contrast, SUL was not correlated with body weight ( r  = 0.23,  p  = 0.07). No significant differences were found between baseline and follow-up scan ( p  = 0.52).    Conclusion  The Janmahasatian formula annuls the positive correlations between SUV and body weight, suggesting that SUL is preferable to SUV for quantitative analyses of  68 Ga-PSMA11 PET/CT scans.

Evaluation of SUV normalized by lean body mass (SUL) in 68Ga-PSMA11 PET/CT: a bi-centric analysis