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Background  This study is an assessment of the impact of acquisition times on SUV with [ 18 F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.    Methods  One hundred six [ 18 F]FDG-PET/CT were acquired in list mode over a single-bed position (livers ( n  = 48) or on tumors ( n  = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUV max  (hottest voxel), SUV peak  (maximum average SUV within a 1-cm 3  spherical volume), and SUV average  were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [ 18 F]FDG avid tumors (SUV max  ≥ 5), the SUV max , SUV peak , and SUV 41%  (isocontour threshold method) were computed.    Results  For tumors, SUV peak  values did not vary with acquisition time. SUV max  displayed significant differences between 1.5- and 5–10-min reconstruction times. SUV 41%  was the most time-dependent parameter. For the liver, the SUV average  was the sole parameter that did not vary over time.    Conclusions  For [ 18 F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUV peak  may be more robust than the SUV max . The SUV average  over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.

For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time