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Background  To investigate whether an apoptotic process demonstrated by  99m Tc-annexin-V ( 99m Tc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed  99m Tc-AV uptake in rat model of myocardial ischemia and reperfusion.    Methods  The left coronary artery (LCA) of 15 rats was occluded for 20 to 30 min, followed by reperfusion. After 2 weeks,  99m Tc-AV was injected, and then 1 h later,  201 Tl was injected after reocclusion of the LCA. Dual-tracer autoradiography was performed to assess  99m Tc-AV uptake and the area at risk (AAR) by  201 Tl defect.  99m Tc-AV uptake ratio was calculated by dividing the count density of the AAR by that of the normally perfused area. In short-axis LV slices, LV cavity dilation index (DI) was calculated by dividing the area of LV cavity by that of the whole LV area. LV wall-thinning ratio (WTR) was calculated by dividing the LV wall thickness in the AAR by that of the normally perfused area.    Results  Significant  99m Tc-AV uptake in the AAR was observed in 10 rats. DI was significantly higher in rats with positive  99m Tc-AV uptake than in rats without uptake. WTR was smaller in rats with positive  99m Tc-AV uptake than in rats without uptake.    Conclusions  The data suggest  99m Tc-AV uptake in injured myocardium might correlate with LVR at 2 weeks after myocardial ischemia and reperfusion.

Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion