English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objectives To investigate the impact of computed tomography (CT)-based, artificial intelligence-driven waist skeletal muscle volume on survival outcomes in patients with endometrial cancer. Methods We retrospectively identified endometrial cancer patients who received primary surgical treatment between 2014 and 2018 and whose pre-treatment CT scans were available ( n  = 385). Using an artificial intelligence-based tool, the skeletal muscle area (cm 2 ) at the third lumbar vertebra (L3) and the skeletal muscle volume (cm 3 ) at the waist level were measured. These values were converted to the L3 skeletal muscle index (SMI) and volumetric SMI by normalisation with body height. The relationships between L3, volumetric SMIs, and survival outcomes were evaluated. Results Setting 39.0 cm 2 /m 2  of L3 SMI as cut-off value for sarcopenia, sarcopenia (&lt; 39.0 cm 2 /m 2 ,  n  = 177) and non-sarcopenia (≥ 39.0 cm 2 /m 2 ,  n  = 208) groups showed similar progression-free survival (PFS;  p  = 0.335) and overall survival (OS;  p  = 0.241). Using the median value, the low-volumetric SMI group (&lt; 206.0 cm 3 /m 3 ,  n  = 192) showed significantly worse PFS (3-year survival rate, 77.3% vs. 88.8%;  p  = 0.004) and OS (3-year survival rate, 92.8% vs. 99.4%;  p  = 0.003) than the high-volumetric SMI group (≥ 206.0 cm 3 /m 3 ,  n  = 193). In multivariate analyses adjusted for baseline body mass index and other factors, low-volumetric SMI was identified as an independent poor prognostic factor for PFS (adjusted HR, 1.762; 95% CI, 1.051–2.953;  p  = 0.032) and OS (adjusted HR, 5.964; 95% CI, 1.296–27.448;  p  = 0.022). Conclusions Waist skeletal muscle volume might be a novel prognostic biomarker in patients with endometrial cancer. Assessing body composition before treatment can provide important prognostic information for such patients.

Prognostic role of computed tomography-based, artificial intelligence-driven waist skeletal muscle volume in uterine endometrial carcinoma