English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features.    Methods  Electrodermal activity (EDA), a non-invasive physiological indicator of autonomic activity, was measured in typically developing children ( n  = 33) and those with ASD ( n  = 38) as participants performed tasks that elicit anxiety, attention, response inhibition, and social cognition processes. The ASD group was divided into low- ( n  = 18) and high-anxiety ( n  = 20) participants, and the groups were compared to mean EDA level and electrodermal reactions frequency (EDR).    Results  The ASD group had a significantly blunted mean EDA response to the anxiety tasks ( p  < 0.004). The EDR response to all tasks, except response inhibition, was also blunted in the ASD group ( p <  0 . 04). For this group, EDR frequency during the anxiety and social cognition tasks was negatively correlated with behavioral scores in the domains that were probed by each task ( p <  0 . 002). The high-anxiety ASD group showed significantly decreased mean EDA compared to both the low-anxiety ASD group ( p  = 0 . 02) and the typically developing control group ( p  = 0 . 04). The high-anxiety ASD group also had significantly more severe symptoms than the low-anxiety ASD group on domains related to anxiety, attention, rule breaking, aggression, obsessions and compulsions, and depression.    Conclusions  Our results suggest atypical autonomic function in children with ASD, specifically with respect to sympathetic activity. Moreover, anxiety symptomatology defined subgroups with distinct physiological and behavioral profiles. Overall, the results add to the body of literature supporting autonomic dysfunction in ASD and highlight the role of anxiety and autonomic features in explaining the variability in the autism spectrum.

Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology