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Background  Alzheimer’s disease (AD) is a progressive and irreversible brain disorder. Hippocampus is one of the involved regions and its atrophy is a widely used biomarker for AD diagnosis. We have recently developed DenseCNN, a lightweight 3D deep convolutional network model, for AD classification based on hippocampus magnetic resonance imaging (MRI) segments. In addition to the visual features of the hippocampus segments, the global shape representations of the hippocampus are also important for AD diagnosis. In this study, we propose DenseCNN2, a deep convolutional network model for AD classification by incorporating global shape representations along with hippocampus segmentations.    Methods  The data was obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and was T1-weighted structural MRI from initial screening or baseline, including ADNI 1,2/GO and 3. DenseCNN2 was trained and evaluated with 326 AD subjects and 607 CN hippocampus MRI using 5-fold cross-validation strategy. DenseCNN2 was compared with other state-of-the-art machine learning approaches for the task of AD classification.    Results  We showed that DenseCNN2 with combined visual and global shape features performed better than deep learning models with visual or global shape features alone. DenseCNN2 achieved an average accuracy of 0.925, sensitivity of 0.882, specificity of 0.949, and area under curve (AUC) of 0.978, which are better than or comparable to the state-of-the-art methods in AD classification. Data visualization analysis through 2D embedding of UMAP confirmed that global shape features improved class discrimination between AD and normal.    Conclusion  DenseCNN2, a lightweight 3D deep convolutional network model based on combined hippocampus segmentations and global shape features, achieved high performance and has potential as an efficient diagnostic tool for AD classification.

Predict Alzheimer’s disease using hippocampus MRI data: a lightweight 3D deep convolutional network model with visual and global shape representations