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Background  Recent studies suggested that  ZMYND10  is a potential tumor suppressor gene in multiple tumor types. However, the mechanism by which  ZMYND10  inhibits breast cancer remains unclear. Here, we investigated the role and mechanism of  ZMYND10  in breast cancer inhibition.    Results   ZMYND10  was dramatically reduced in multiple breast cancer cell lines and tissues, which was associated with promoter hypermethylation. Ectopic expression of  ZMYND10  in silenced breast cancer cells induced cell apoptosis while suppressed cell growth, cell migration and invasion  in vitro,  and xenograft tumor growth in vivo. Furthermore, molecular mechanism studies indicated that  ZMYND10  enhances expression of miR145-5p, which suppresses the expression of  NEDD9  protein through directly targeting the 3'-untranslated region of  NEDD9  mRNA.    Conclusions  Results from this study show that  ZMYND10  suppresses breast cancer tumorigenicity by inhibiting the miR145-5p/ NEDD9  signaling pathway. This novel discovered signaling pathway may be a valid target for small molecules that might help to develop new therapies to better inhibit the breast cancer metastasis.

ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer