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Objective  Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene ( FTO ) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated  FTO  rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models.    Results  Only individuals with the CC genotype had a considerably higher BMI ( p  < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant:  p  < 0.010, over-dominant:  p  < 0.030, additive:  p  < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%,  p  = 0.046) and saturated fatty acid (SAFA; 2.06%,  p  = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between  FTO  rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of  FTO  gene in food preference, and its influence on body weight.    Supplementary Information  The online version contains supplementary material available at 10.1186/s13104-021-05823-1.

Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults