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Objective  Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of  GSTT1  and  GSTM1  genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment.    Results  In the present study, 57.5% (115/200) of patients had their hypertension under control. No statistically significant difference was found between controlled and uncontrolled groups for anthropometric and biochemical parameters as well as for  GSTT1  or  GSTM1  gene polymorphisms (all  p  > 0.05). Current alcohol consumption (OR = 3.04; CI 1.88–6.13;  p  < 0.001), Physical inactivity (OR = 3.07; CI 1.71–5.49;  p  < 0.001), severe hypertension before any treatment (Grade III [OR = 3.79; CI 2.00–7.17;  p  < 0.001]) and heart damage (OR = 3, 14; CI 1.59–6.02;  p  < 0.001) were statistically more frequent in uncontrolled essential hypertensive patients than controlled hypertensive patients.    Supplementary Information  The online version contains supplementary material available at 10.1186/s13104-021-05658-w.

bmc research notes

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso