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Objectives  We and others have shown that  Aspilia pluriseta  is associated with various biological activities. However, there is a lack of information on its cytotoxicity. This has created an information gap about the safety of  A. pluriseta  extracts. As an extension to our recent publication on the antimicrobial activity and the phytochemical characterization of  A. pluriseta  root extracts, here we report on cytotoxicity of tested solvent fractions. We evaluated the potential cytotoxicity of these root extract fractions on Vero cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.    Results  We show that all solvent extract fractions (except methanolic solvent fractions) had cytotoxic concentration values that killed 50% of the Vero cells (CC 50 ) greater than 20 µg/mL and selectivity index (SI) greater than 1.0. Taken together, we demonstrate that,  A. pluriseta  extract fractions’ earlier reported bioactivities are within the acceptable cytotoxicity and selective index limits. This finding scientifically validates the potential use of  A. pluriseta  in the discovery of safe therapeutics agents.

In vitro cytotoxicity of Aspilia pluriseta Schweinf. extract fractions