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Objective  Coagulase-negative  staphylococci  (CoNS) are as considered opportunistic pathogens which capable of producing several toxins, enzymes and resistance genes. The current study aimed to determine the occurrence of different hemolysins genes and patterns of antibiotic resistance among CoNS species.    Results  The highest frequency of antibiotic resistance was observed against cefoxitin in 49 isolates (53.8%), and the lowest resistance was against novobiocin in 5 isolates (5.5%). None of the isolates was resistant to vancomycin. The prevalence of  hla, hla_yidD, hld,  and  hlb  genes was: 87.9%, 62.6%, 56%, and 47.3%, respectively. The  hla/yidD  and  hld  genes were detected in 69.4% of  S. epidermidis  and the  hla  gene in 94.6% of  S. haemolyticus  isolates; the  hlb  gene was detected in 53.1% of the  S. epidermidis  isolates. The  mecA  gene was identified in 50 (55%) of the CoNS isolates. In conclusion, the results of statistical analysis showed that the  hld gene  had a significant association with resistance to levofloxacin and erythromycin antibiotics, the  hlb  with clindamycin resistance and the  hla/yidD  with rifampicin and novobiocin resistance. The results of this study showed that there is a significant relationship between hemolysin encoding genes and antibiotic resistance patterns; therefore, detection of virulence factors associated with antibiotic resistance has become a significant issue of concern.

bmc research notes

Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci