English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective  Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between  miR - 196a2  (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the  miR - 196a2  variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study.    Results  The statistical analysis showed no significant relationship for allele and frequencies of  miR - 196a2  genotype between patients and controls ( p  >  0.05 ). Log-rank test showed that gender has highly significant impact on both OS and PFS ( p  =  0.027, p  =  0.045).  In the univariate analysis, TT genotype ( p  =  0.022 ), and CT/TT ( p  =  0.008 ) had better OS. In the multivariate analysis, CC/CT-TT were associated with positively OS ( p  =  0.041 ). Currently, the most valuable prognostic markers in MM that has clinical implication are genetic abnormalities. It can be concluded from the results that  miR - 1962a  variant is effective in prognosis of the MM. It is believed that these findings will help us understand the molecular basis of disease.

The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma