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Objective  SLITs are secreted glycoproteins that bind to Roundabouts (ROBOs) which are a family member of transmembrane receptors. SLIT signaling has well-conserved roles in mediating axon repulsion in a developing nervous system. We previously reported that  SLIT1  mRNA is enriched in middle layers of the prefrontal cortex of macaque monkeys in a developmentally regulated manner. Other  SLIT  ( SLIT2  and  SLIT3 ) mRNAs showed preferential expressions in the prefrontal cortex with a distinct laminar pattern. To obtain further clues to the role of SLIT signaling in the organization of the primate brain, we performed ISH analysis of  SLIT  and  ROBO  mRNAs using adult macaque brain tissues.    Results  In this study, we examined the expression patterns of  SLITs  and  ROBOs  ( ROBO1  and  ROBO2 ) in other brain regions, and found intense and characteristic expression patterns of these genes in the entorhinal-hippocampal area. In situ hybridization analysis revealed that  SLIT1  and  SLIT2  mRNAs showed marked complementary distribution in the entorhinal cortex.  SLIT  and  ROBO  mRNAs were widely expressed in the hippocampus with modest regional preference. These findings suggest that each  SLIT  gene has a specialized role that is particularly important for prefrontal as well as hippocampal connectivity in the primate cortex.

Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys