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Objective  The present study was carried out to investigate the transcriptional response of marA (Multiple antibiotic resistance A gene), soxS (Superoxide S gene) and rob (Right-origin-binding gene) under carbapenem stress.    Results  12 isolates were found over-expressing AcrAB-TolC efflux pump system and showed reduced expression of OmpF (Outer membrane porin) gene were selected for further study. Among them, over expression of  marA  and  rob  was observed in 7 isolates. Increasing pattern of expression of  marA  and rob against meropenem was observed. The clones of  marA  and rob showed reduced susceptibility towards carbapenems.

bmc research notes

Transcriptional response of mar, sox and rob regulon against concentration gradient carbapenem stress within Escherichia coli isolated from hospital acquired infection