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Objective  NRK is a unique X chromosome-linked protein kinase expressed predominantly in placenta. The gene knockout causes placental overgrowth and delayed labor of  Nrk -null fetuses from dams in mouse. To clarify unknown mechanisms behind the  Nrk -null phenotypes, protein expression profiles were analyzed in the  Nrk -null placenta using a high-performance two-dimensional electrophoresis methodology.    Results  Among around 1800 spots detected, we characterized a dozen protein spots whose expression levels were significantly altered in the  Nrk -null placenta compared to wild-type. Analyzing these data sets is expected to reflect the difference physiologically in the presence or absence of NRK, facilitating the development of therapeutic strategies.

Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK