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Objective  Methicillin-resistant  Staphylococcus aureus  cause to a variety of hard to cure infections. MRSA isolates also, produce an arsenal of virulence factors contribute to severe infections. The aim of this study was to find out the relationship between  agr  locus and presence of  S. aureus  superantigens (SAgs).    Results  Clinical isolates in two groups from two different states of Iran were collected. Antibiotic resistance patterns,  agr  typing, and virulence factor genes prevalence were identified and relationship between them was analyzed using SPSS software version16. Most of the samples were collected from wound 39 isolates in Group 1 and 61 isolates in Group 2. Frequency of MRSA strains was 38.1% in Group 1 and 52.1% in Group 2. Also, the most common resistance among both groups was to penicillin.  agr  positive isolates were detected in 132 isolates of Group 1 and 104 isolates of Group 2. In Conclusion, a significant relationship between the SAgs frequency and  agr  locus in both groups has been indicated. The production of superantigens in  S. aureus  plays an important role in the classification of  agr  locus, and this locus can affect differently in methicillin-resistant strains.    Electronic supplementary material  The online version of this article (10.1186/s13104-019-4166-7) contains supplementary material, which is available to authorized users.

bmc research notes

Association between the accessory gene regulator (agr) locus and the presence of superantigen genes in clinical isolates of methicillin-resistant Staphylococcus aureus