English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives  The relevance of  Escherichia coli  associated bacteriuria infection in pregnant women is poorly understood, despite these strains sharing a similar virulence profile with other pathogenic  E. coli  causing severe obstetric and neonatal infections. We characterized and determined the antimicrobial susceptibility, resistance genes and virulence profiles of 82  E. coli  isolates associated with asymptomatic bacteriuria in some pregnant in Ghana from February to August 2016 using Kirby–Bauer disc diffusion and polymerase chain reaction.    Results  High levels of antimicrobial resistance were observed to ampicillin (79.3%), tetracycline (70.7%) and cotrimoxazole (59.8%), except for cefuroxime (32.9%). Resistance genes analyses revealed 58.5% were positive for  Bla  TEM  and 7.3% for  aph(3) - Ia (aphA2). Virulence factors (VFs) was more widespread in pregnant women in the 2nd and 3rd trimesters than 1st trimester. VFs relating to adhesion ( pap C and  iha ), Protectins ( tra T), aerobactin acquisition ( iut A) and iron acquisition systems ( fyu A and  irp 2) were more prevalent in the resistant  E. coli  isolates. This study provides evidence for a link in bacteriuria and transmission of extra-intestinal  E. coli  in pregnant women to cause multi-resistant obstetric or neonatal infections. Considering the involvement of extra-intestinal  E. coli  in infections, results are helpful to develop strategies to prevent maternal and/ neonatal infections.    Electronic supplementary material  The online version of this article (10.1186/s13104-018-3989-y) contains supplementary material, which is available to authorized users.

Escherichia coli bacteriuria in pregnant women in Ghana: antibiotic resistance patterns and virulence factors