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Objective  The aim of this study was to investigate the antiplasmodial effects of the crude aqueous, methanol and chloroform extracts of the leaves of  Vernonia adoensis  in  Plasmodium berghei  infected Swiss albino mice using Peters’ 4-day suppressive test.    Results  The number of mice used for the toxicity test was 20 (5/group) and for each extract and control groups 5 mice per group was used. The aqueous, methanol and chloroform extracts of  V. adoensis  leaves indicated statistically significant (P < 0.05) suppression of parasitaemia in the treated mice. The highest inhibition was that of the methanol extract treated mice (83.36%) followed by aqueous (72.26%) and chloroform (54.34%) at an oral dose of 600 mg/kg b.wt. Each extract prevented body weight loss and packed cell volume (PCV) reduction as compared to the negative control groups. The survival time of the mice treated with chloroform based on Kaplan–Meir analysis was 12.53 ± 0.37 at 600 mg/kg b.wt, while the negative control was 7.93 ± 0.37 days. The LD 50  of the extracts was greater than 3000 mg/kg body weight. In conclusion, the crude leaves extract of  V. adoensis  have demonstrated antiplasmodial effect in vivo.  P. berghei  infection is suppressed in a dose-dependent manner showing relevance of the traditional use of the plant.    Electronic supplementary material  The online version of this article (10.1186/s13104-018-3835-2) contains supplementary material, which is available to authorized users.

bmc research notes

Antiplasmodial activity of Vernonia adoensis aqueous, methanol and chloroform leaf extracts against chloroquine sensitive strain of Plasmodium berghei in vivo in mice