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Objective  Chloride (Cl − ) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl −  secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl −  secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl −  secretion in the ileum. The aim of this study was to gain further insights regarding the effects of RSV on characteristics of Cl −  secretion in the porcine ileum using the Ussing chamber technique (recording of short circuit currents (I sc ) as a measure for epithelial net ion transfer).    Results  RSV increased the I sc  in the porcine ileum but not in the porcine jejunum as is already known. This increase was absent in a Cl − -free buffer system, indicating that RSV indeed induces Cl −  secretion. However, the carbachol-induced I sc  was significantly inhibited by RSV indicating an inhibition of Ca 2+ -induced Cl −  secretion. The cellular basis for these contradictory, segment specific results of RSV on Cl −  secretion has to be subjected to further studies. The results also underline, that is difficult to generalize effects of RSV between different intestinal locations, organs, cell culture models or species.    Electronic supplementary material  The online version of this article (10.1186/s13104-018-3825-4) contains supplementary material, which is available to authorized users.

Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue