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Objectives  ESBL-producing isolates of the  Enterobacteriaceae  occur throughout the world. The objectives of this study were to characterize uropathogenic  Escherichia coli  isolated at a tertiary care hospital in southern India, and shed light on  bla  CTX-M  sequences of Indian origin.    Results  A cohort of 13 urinary isolates of  E. coli  (obtained from patients at the Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, Andhra Pradesh, India) were characterized and found to be resistant to multiple antibiotics, including extended-spectrum cephalosporins. All 13 isolates contained  bla  CTX-M-15 , and many of them transferred this genotype to at least one laboratory strain of  E. coli  after conjugation. Analyses of  bla  CTX-M-15  sequences (n = 141) of Indian origin showed that > 85% of them were obtained from bacteria not associated with the urinary tract, and that  E. coli  isolates account for majority of all  bla  CTX-M-15 -carrying bacteria reported from India. Other types of  bla  CTX-M  appear to be rare in India, since only six such sequences were reported as of July 2015. The results indicate that ‘selection pressure’ exerted by extended-spectrum cephalosporins may have stabilized the  bla  CTX-M-15  genotype among  E. coli  in India. The rarity of other  bla  CTX-M  suggests that they lack the survival advantage that  bla  CTX-M-15  may have.    Electronic supplementary material  The online version of this article (10.1186/s13104-018-3735-5) contains supplementary material, which is available to authorized users.

Characterization of blaCTX-M sequences of Indian origin and thirteen uropathogenic Escherichia coli isolates resistant to multiple antibiotics