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Objective  Self-medication is defined as use of medicines to treat self-recognized illnesses. It is widely used in Ethiopia. However, its extent of use is unknown among health professionals. This study aimed to assess prevalence and reasons of self-medication with modern medicines among health professionals. A cross-sectional study was conducted on the health professionals, working in the public health facilities. Data were collected from March to May, 2016 using semi-structured questionnaire. Data were entered and analyzed using statistical package for the social sciences. A chi square test was used as test of significance at 95% of confidence interval.    Results  A total of 154 health professionals were enrolled, with 53% were being females. The finding revealed that prevalence of self-medication with modern medicines was 67.5%. Financial constraints (32.5%) and familiarity with medicines (24%) were the major reasons of self-medication. It also showed that self-medication with modern medicines was significantly associated with marital status (χ 2  = 19.57, P = 0.00). Analgesics (53%) and antibiotics (36%) were the most commonly used categories of medicines. Self-medication with modern medicines was highly practiced among health professionals. Financial constraints and familiarity with medicines were the two major reasons of practicing.

Epidemiology of self-medication with modern medicines among health care professionals in Nekemte town, western Ethiopia