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Objective  We have previously demonstrated that unencapsulated  Enterococcus faecalis  cps2 inhibits biofilm formation of  Candida albicans , a fungus commonly found with  E. faecalis  in periapical lesion. In this study, we compared encapsulated and unencapsulated  E. faecalis  cps2 strains relationship with osteoblastic (MG-63) cells, whereas  E. faecalis  ATCC 29212 were used as a reference strain.    Results  The binding capacity of  E. faecalis  to MG-63 cells as shown by each tested strain was comparable, but the unencapsulated strain was less invasive compared to the encapsulated and the reference strains. Moreover, quantitative real time-PCR (qPCR) results showed that infecting unencapsulated  E. faecalis  cps2 is a stronger stimulator for toll like receptor 2 (TLR2) and interleukin-1β (IL-1β) mRNAs, but not for inducible nitric oxide synthase (iNOS) mRNA in osteoblastic cells. In conclusion, the performance of unencapsulated  E. faecalis  cps2 when the bacterium interacts with osteoblastic cells is quite different from that of encapsulated  E. faecalis  cps2 and reference strains. It appears that the unencapsulated strain might contribute to the persistence of the periapical inflammatory response, depending on down-regulation of iNOS mRNA expression.

Proinflammatory MG-63 cells response infection with Enterococcus faecalis cps2 evaluated by the expression of TLR-2, IL-1β, and iNOS mRNA