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Objectives    Candida dubliniensis  is an emerging yeast and demonstrated a high adherence property to cystic fibrosis respiratory tract. Therefore, it is important to determine the persistence of  C .  dubliniensis  and to assess the possible relationship to the body mass index (BMI) and forced expiratory volume in 1st second (FEV1).    Results    Candida  isolates were identified by MALDI-TOF MS to species level from 40/52 (76.9%) cystic fibrosis patients.  C. dubliniensis  was the most common organism isolated from 50/77 (65%) lower respiratory specimens of 29 patients. Patients with persistent  C. dubliniensis  isolates have higher mean BMI in comparison to intermittent  C. dubliniensis  group. However, this difference did not reach statistical significance (P = 0.539). In contrast, patients with persistent  C. dubliniensis  isolates have significantly lower FEV1% mean in comparison to intermittent  C. dubliniensis  group particularly at initial two visits (P < 0.05); however, at subsequent visit the difference observed was not statistically significant (P = 0.456). The persistence of  C. dubliniensis  is more frequent in adults having more advanced disease, co-infections with chronic  P. aeruginosa , cystic fibrosis related diabetes, long-term nebulized tobramycin and oral Zithromax therapy than patients with intermittent  C. dubliniensis.  Patients with persistent  C. dubliniensis  have lower FEV1 percentage and higher BMI than the intermittent  C. dubliniensis .

Persistence of Candida dubliniensis and lung function in patients with cystic fibrosis