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Objective    “   Candidatus  Ruthia magnifica”, “ Candidatus  Vesicomyosocius okutanii” and  Thiomicrospira crunogena  are all sulfur-oxidising bacteria found in deep-sea vent environments. Recent research suggests that the two symbiotic organisms, “ Candidatus  R. magnifica” and “ Candidatus  V. okutanii”, may share common ancestry with the autonomously living species  T. crunogena . We used comparative genomics to examine the genome-wide protein-coding content of all three species to explore their similarities. In particular, we used the OrthoMCL algorithm to sort proteins into groups of putative orthologs on the basis of sequence similarity.    Results  The OrthoMCL inflation parameter was tuned using biological criteria. Using the tuned value, OrthoMCL delimited 1070 protein groups. 63.5% of these groups contained one protein from each species. Two groups contained duplicate protein copies from all three species. 123 groups were unique to  T. crunogena  and ten groups included multiple copies of  T. crunogena  proteins but only single copies from the other species. “ Candidatus  R. magnifica” had one unique group, and had multiple copies in one group where the other species had a single copy. There were no groups unique to “ Candidatus  V. okutanii”, and no groups in which there were multiple “ Candidatus  V. okutanii” proteins but only single proteins from the other species. Results align with previous suggestions that all three species share a common ancestor. However this is not definitive evidence to make taxonomic conclusions and the possibility of horizontal gene transfer was not investigated. Methodologically, the tuning of the OrthoMCL inflation parameter using biological criteria provides further methods to refine the OrthoMCL procedure.

bmc research notes

Comparison of the protein-coding genomes of three deep-sea, sulfur-oxidising bacteria: “Candidatus Ruthia magnifica”, “Candidatus Vesicomyosocius okutanii” and Thiomicrospira crunogena