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Background  Resistance development in human malaria parasites against commonly used antimalarial drugs has necessitated the scientific exploration of traditionally used antimalarial plants. Plant derivatives have been used for curing malaria historically. The present study involves in vitro evaluation of two medicinally important plants  Aristolochia griffithii  and  Thalictrum foliolosum  DC used in antimalarial chemotherapy by the tribes of northeast India.    Method  Chloroform, ethyl acetate and n–butanol extracts of  Aristolochia griffithii  and  Thalictrum foliolosum  DC were evaluated in vitro against chloroquine sensitive (SS) and chloroquine resistance strains (RS) of  P. falciparum . The tests were conducted following WHO standard method and the inhibition of parasite (IC 50 ) was calculated.    Results  In  A. griffithii , the IC 50  value for ethyl acetate extracts against SS was 6.2 ± 0.02 μg/ml and found to be lower than chloroform extracts, which exhibited an IC 50  value of 14.1 ± 0.1 μg/ml (t = 191.1; p < 0.0001). The IC 50  values of both chloroform and ethyl acetate extracts for RS were higher as compared to the SS (p < 0.0001). In  T. foliolosum  DC the IC 50  concentration of chloroform extracts for SS and RS were 0.5 ± 0.0 and 1.1 ± 0.0 μg/ml respectively (t = 54.2; p < 0.0001).    Conclusion  The present findings, although preliminary, but scientifically demonstrate that identification and isolation of active compounds of these two plant materials and testing against different  Plasmodium  species could lead to the development of potential antimalarial drugs for future.

bmc research notes

Preliminary in vitro antiplasmodial activity of Aristolochia griffithii and Thalictrum foliolosum DC extracts against malaria parasite Plasmodium falciparum