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Background  The transcription factor 7-like 2 ( TCF7L2 ) is one of the genes that have been identified as possible determinants of diabetes which is associated with obesity. Data on the genetic causes of obesity in sub-Saharan African populations are very scares. The aim of this study was to assess the association between the transcription factor 7-like 2 ( TCF7L2 ) gene polymorphism (rs12255372 G/T) and obesity and weight-related traits  in a Cameroonian population.    Methods  A case–control study was conducted on 35  obese and 30 non-obese Cameroonian adults.  TCF7L2  rs12255372 genotypes were determined using PCR–RFLP and correlated with BMI and weight-related traits.    Results  No significant association was observed between the rs12255372 T allele (χ 2  = 0.0684, p = 0.79) or the TT genotype (χ 2  = 0.372, p = 0.54) of the TCF7L2 gene and obesity in the Cameroonian population. However, amongst the weight-related traits, triglycerides were significantly associated with the T risk allele of the TCF7L2 gene (p = 0.012).    Conclusion  This study on Cameroonian subjects replicates the absence of association between the  TCF7L2  rs12255372 variant and obesity as observed in European and American populations.

Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population