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Background  Auditory and vestibular disorders are prevalent sensory disabilities caused by genetic and environmental (noise, trauma, chemicals) factors that often damage mechanosensory hair cells of the inner ear. Development of treatments for inner ear disorders of hearing and balance relies on the use of animal models such as fish, amphibians, reptiles, birds, and non-human mammals. Here, we aimed to augment the utility of the genus  Xenopus  for uncovering genetic mechanisms essential for the maintenance of inner ear structure and function.    Results  Using  Affymetrix  GeneChip ®  X. laevis  Genome 2.0 Arrays and Illumina-Solexa sequencing methods, we determined that the transcriptional profile of the  Xenopus  laevis  inner ear comprises hundreds of genes that are orthologous to OMIM ®  genes implicated in deafness and vestibular disorders in humans. Analysis of genes that mapped to both technologies demonstrated that, with our methods, a combination of microarray and RNA-Seq detected expression of more genes than either platform alone.    Conclusions  As part of this study we identified candidate scaffold regions of the  Xenopus tropicalis  genome that can be used to investigate hearing and balance using genetic and informatics procedures that are available through the National  Xenopus  Resource (NXR), and the open access data repository,  Xenbase . The results and approaches presented here expand the viability of  Xenopus  as an animal model for inner ear research.    Electronic supplementary material  The online version of this article (doi:10.1186/s13104-015-1485-1) contains supplementary material, which is available to authorized users.

bmc research notes

RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM® genes for hereditary disorders of hearing and balance