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Background  In Ethiopia, where malaria and schistosomiasis are co-endemic, co-infections are expected to be high. However, data about the prevalence of malaria-schistosomiasis co-infection and their clinical correlation is lacking. Therefore, the aim of this study was to assess prevalence of  Schistosoma mansoni  co-infection and associated clinical correlates in malaria patients.    Methods  A cross-sectional study was conducted in 2013 at Chwahit Health Center, in northwest Ethiopia. Blood film positive malaria patients (N = 205) were recruited for the study. Clinical, parasitological, hematological, and biochemical parameters were assessed from every study participant. Stool samples were also collected and processed with Kato-Katz technique to diagnose and classify intensity of  Schistosoma mansoni .    Results  The prevalence of  Schistosoma mansoni  and malaria co-infection was 19.5 %. The age group of 16–20 years old was significantly associated with co-infection. Co-infected patients with a moderate-heavy egg burden of  Schistosoma mansoni  had significantly high mean  Plasmodium  parasitemia. On the other hand, age group of 6–10 years old and moderate-heavy  Schistosoma mansoni  co-infection were significantly associated with severe malaria.    Conclusions  Prevalence of malaria and  Schistosoma mansoni  co-infection in the study area was considerably high. Severity of malaria and parasitemia of  Plasmodium  were associated with certain age groups and intensity of concurrent  Schistosoma mansoni . Further study is needed to explore the underlying mechanisms of interaction between malaria and  Schistosoma mansoni .

Prevalence and clinical correlates of Schistosoma mansoni co-infection among malaria infected patients, Northwest Ethiopia