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Genomics and other large-scale analyses have drawn increasing attention to the potential impacts of transposable elements (TEs) on their host genomes. However, it remains challenging to transition from identifying potential roles to clearly demonstrating the level of impact TEs have on genome evolution and possible functions that they contribute to their host organisms. I summarize TE content and distribution in four well-characterized yeast model systems in this review: the pathogens  Candida albicans  and  Cryptococcus neoformans , and the nonpathogenic species  Saccharomyces cerevisiae  and  Schizosaccharomyces pombe . I compare and contrast their TE landscapes to their lifecycles, genomic features, as well as the presence and nature of RNA interference pathways in each species to highlight the valuable diversity represented by these models for functional studies of TEs. I then review the regulation and impacts of the Ty1 and Ty3 retrotransposons from  Saccharomyces cerevisiae  and Tf1 and Tf2 retrotransposons from  Schizosaccharomyces pombe  to emphasize parallels and distinctions between these well-studied elements. I propose that further characterization of TEs in the pathogenic yeasts would enable this set of four yeast species to become an excellent set of models for comparative functional studies to address outstanding questions about TE-host relationships.

Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective