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Background  Although  Escherichia coli  is the most frequently isolated microorganism in acute biliary tract infections with bacteremia, data regarding its virulence are limited.    Results  Information on cases of bacteremia in acute biliary tract infection in a retrospective study was collected from 2013 to 2015 at a tertiary care hospital in Japan. Factors related to the severity of infection were investigated, including patient background, phylogenetic typing, and virulence factors of  E. coli , such as adhesion, invasion, toxins, and iron acquisition.  In total, 72  E. coli  strains were identified in 71 cases, most of which primarily belonged to the B2 phylogroup (68.1%). The presence of the  iutA  gene (77.3% in the non-severe group, 46.4% in the severe group,  P  = 0.011) and the  ibeA  gene (9.1% in the non-severe group, and 35.7% in the severe group,  P  = 0.012) was significantly associated with the severity of infection. Among the patient characteristics, diabetes mellitus with organ involvement and alkaline phosphatase were different in the severe and non-severe groups.    Conclusions  We showed that bacteremic  E. coli  strains from acute biliary tract infections belonged to the virulent (B2) phylogroup. The prevalence of the  iutA  and  ibeA  genes between the two groups of bacteremia severity was significantly different.

gut pathogens

The prevalence of the iutA and ibeA genes in Escherichia coli isolates from severe and non-severe patients with bacteremic acute biliary tract infection is significantly different