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Background  The membrane fusion protein ( mfp ) gene locus of  Vibrio parahaemolyticus  consists of two operons,  cpsQ - mfpABC  and  mfpABC , which are both required for biofilm formation. ToxR and CalR are required for the full virulence of  V. parahaemolyticus , and their mutual regulation has been demonstrated. Moreover, cell density-dependent expression of  toxR  was previously observed in  V. parahaemolyticus , but details about the related mechanisms remained unclear. QsvR can work with the master quorum sensing (QS) regulators AphA and OpaR to regulate virulence expression and biofilm formation.    Results  In the present work, we showed that QsvR bound to the promoter-proximal DNA regions of  toxR  and  calR  to repress their transcription as well as occupying the regulatory regions of  cpsQ - mfpABC  and  mfpABC  to activate their transcription. Thus, we reconstructed the QsvR-dependent promoter organization of  toxR ,  calR ,  cpsQ - mfpABC , and  mfpABC .    Conclusion  QsvR directly repressed  toxR  and  calR  transcription as well as directly activated  cpsQ - mfpABC  and  mfpABC  transcription. The data presented here promotes us to gain deeper knowledge of the regulatory network of the  mfp  locus in  V. parahaemolyticus .

Transcriptional regulation of the virulence genes and the biofilm formation associated operons in Vibrio parahaemolyticus