English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Campylobacter concisus  is an emerging enteric pathogen that is associated with inflammatory bowel disease. Previous studies demonstrated that  C. concisus  is non-saccharolytic and hydrogen gas (H 2 ) is a critical factor for  C. concisus  growth. In order to understand the molecular basis of the non-saccharolytic and H 2 -dependent nature of  C. concisus  growth, in this study we examined the pathways involving energy metabolism and oxidative stress defence in  C. concisus . Bioinformatic analysis of  C. concisus  genomes in comparison with the well-studied enteric pathogen  Campylobacter jejuni  was performed. This study found that  C. concisus  lacks a number of key enzymes in glycolysis, including glucokinase and phosphofructokinase, and the oxidative pentose phosphate pathway.  C. concisus  has an incomplete tricarboxylic acid cycle, with no identifiable succinyl-CoA synthase or fumarate hydratase.  C. concisus  was inferred to use fewer amino acids and have fewer candidate substrates as electron donors and acceptors compared to  C. jejuni . The addition of DMSO or fumarate to media resulted in significantly increased growth of  C. concisus  in the presence of H 2  as an electron donor, demonstrating that both can be used as electron acceptors. Catalase, an essential enzyme for oxidative stress defence in  C. jejuni , and various nitrosative stress enzymes, were not found in the  C. concisus  genome. Overall,  C. concisus  is inferred to have a non-saccharolytic metabolism in which H 2  is central to energy conservation, and a narrow selection of carboxylic acids and amino acids can be utilised as organic substrates. In conclusion, this study provides a molecular basis for the non-saccharolytic and hydrogen-dependent nature of  C. concisus  energy metabolism pathways, which provides insights into the growth requirements and pathogenicity of this species.

Analyses of energy metabolism and stress defence provide insights into Campylobacter concisus growth and pathogenicity