English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   Janibacter melonis  and other member of this genus are known to cause bacteremia and serious clinical comorbidities, but there is no study reporting about pathogenicity attributes of  J. melonis. Janibacter terrae  is known to cause lethal infection. Reporting the genome of  J. melonis  CD11-4 and comparative genomics with other members of genus has provided some novel insights that can enable us to understand the mechanisms responsible for its pathogenicity in humans.    Results  Comparative genomic analysis by Rapid Annotation Server and Technology revealed the presence of similar virulence determinant genes in both  J. terrae  NBRC 107853 T  and  J. melonis  CD11-4. Like  J. terrae  NBRC 107853 T ,  J. melonis  CD11-4 contained two genes responsible for resistance against β-lactam class of antibiotics and two genes for resistance against fluoroquinolones. Interestingly,  J. melonis  CD11-4 contained a unique gene coding for multidrug resistance efflux pumps unlike all other members of this genus. It also contained two genes involved in Toxin-antitoxin Systems that were absent in  J. terrae  NBRC 107853 T  but were present in some other members of genus.    Conclusions  Genome annotations of  J. melonis  CD11-4 revealed that it contained similar or more virulence repertoire like  J. terrae  NBRC 107853 T . Like other gut pathogens,  J. melonis  possesses key virulence determinant genes for antibiotic resistance, invasion, adhesion, biofilm formation, iron acquisition and to cope with stress response, thereby indicating that strain  J. melonis  CD11-4 could be a gut pathogen.

Genome sequence and comparative genomic analysis of a clinically important strain CD11-4 of Janibacter melonis isolated from celiac disease patient