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Background  Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether  Clostridium butyricum  CGMCC0313-1 ( C. butyricum ) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy.    Methods  The preventive and therapeutic effects of oral  C. butyricum  on anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+ CD25+ Foxp3Treg cell and histopathological alterations were examined.    Results    Clostridium butyricum  significantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+ CD25+ Foxp3Treg cell were increased by oral  C. butyricum . It also reversed the imbalance of Th1/Th2 andTh17/Treg.    Conclusions    Clostridium butyricum  reduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.

Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy