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Background  Pathogenic strains in  Escherichia coli  can be divided into several pathotypes according to their virulence features. Among them, uropathogenic  E. coli  causes most of the urinary tract infections and has a genotype distinct from other virulent strains of  E. coli . In this study, we sequenced and analyzed the genome of  E. coli  NCCP15653 isolated from the feces of a diarrhea patient in 2007 in South Korea.    Results  A phylogenetic tree based on MLST showed that NCCP15653 belongs to the D group of  E. coli  and located in the lineage containing strains ST2747, UMN026 and 042. In the genome of NCCP15653, genes encoding major virulence factors of uropathogenic  E. coli  were detected. They include type I fimbriae, hemin uptake proteins, iron/manganese transport proteins, yersiniabactin siderophore proteins, type VI secretion proteins, and hemolysin. On the other hand, genes encoding AslA, OmpA, and the K1 capsule, which are virulence factors associated with invasion of neonatal meningitis-causing  E. coli , were also present, while a gene encoding CNF-1 protein, which is a cytotoxic necrotizing factor 1, was not detected.    Conclusions  Through the genome analysis of NCCP15653, we report an example of a genome of chimeric pathogenic properties. The gene content of NCCP15653, a group D strain, demonstrates that it could be both uropathogenic  E. coli  and neonatal meningitis-causing  E. coli . Our results suggest the dynamic nature of plastic genomes in pathogenic strains of  E. coli .

Genome sequence of Escherichia coli NCCP15653, a group D strain isolated from a diarrhea patient