English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  The varied clinical presentations of  Helicobacter pylori  ( H. pylori ) infection are most likely due to differences in the virulence of individual strains, which determines its ability to induce production of interleukin-8 (IL-8) in the gastric mucosa. The aim of this study was to examine association between  cagA, vacA- s1 and  vacA- s2 genotypes of  H. pylori  and severity of chronic gastritis and presence of peptic ulcer disease (PUD), and to correlate these with IL-8 levels in the gastric mucosa.    Methods  Gastric mucosal biopsies were obtained from patients during esophagogastroduodenoscopy. The severity of chronic gastritis was documented using the updated Sydney system.  H. pylori cagA  and  vacA  genotypes were detected by PCR. The IL-8 levels in the gastric mucosa were measured by ELISA.    Results   H. pylori cagA  and/or  vacA  genotypes were detected in 99 patients (mean age 38.4±12.9; 72 males), of whom 52.5% were positive for  cagA , 44.4% for  vacA -s1 and 39.4% for  vacA -s2; and 70.7% patients had PUD. The severity of inflammation in gastric mucosa was increased with  vacA -s1 (p=0.017) and decreased with  vacA -s2 (p=0.025), while  cagA  had no association. The degree of neutrophil activity was not associated with either  cagA  or  vacA -s1, while  vacA -s2 was significantly associated with decreased neutrophil activity (p=0.027). PUD was significantly increased in patients with  cagA  (p=0.002) and  vacA -s1 (p=0.031), and decreased in those with  vacA -s2 (p=0.011). The level of IL-8 was significantly increased in patients with  cagA  (p=0.011) and  vacA -s1 (p=0.024), and lower with  vacA -s2 (p=0.004). Higher levels of IL-8 were also found in patients with a more severe chronic inflammation (p=0.001), neutrophil activity (p=0.007) and those with PUD (p=0.001).    Conclusions  Presence of  vacA -s1 genotype of  H. pylori  is associated with more severe chronic inflammation and higher levels of IL-8 in the gastric mucosa, as well as higher frequency of PUD. Patients with  vacA -s2 have less severe gastritis, lower levels of IL-8, and lower rates of PUD. The presence of  cagA  genotype is not associated with the severity of gastritis or IL-8 induction in the gastric mucosa. The association of  cagA  with PUD may be a reflection of its presence with  vacA -s1 genotype.

gut pathogens

Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East