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Background  Meniscal calcification is considered to play a relevant role in the pathogenesis of osteoarthritis of the knee. Little is known about the biology of acetabular labral disease and its importance in hip pathology. Here, we analyze for the first time the calcification of the acetabular labrum of the hip (ALH) and its relation to hip cartilage degeneration.    Methods  In this cross-sectional post-mortem study of an unselected sample of the general population, 170 ALH specimens and 170 femoral heads from 85 donors (38 female, 47 male; mean age 62.1 years) were analyzed by high-resolution digital contact radiography (DCR) and histological degeneration grade. The medial menisci (MM) from the same 85 donors served as an intra-individual reference for cartilage calcification (CC). Scanning electron microscopy (SEM), energy dispersive analysis (ED) and Raman spectroscopy were performed for characterization of ALH CC.    Results  The prevalence of CC in the ALH was 100% and that in the articular cartilage of the hip (ACH) was 96.5%. Quantitative analysis revealed that the amount of ALH CC was higher than that in the ACH (factor 3.0,  p  < 0.001) and in the MM (factor 1.3,  p  < 0.001). There was significant correlation between the amount of CC in the fibrocartilage of the left and right ALH ( r  = 0.70,  p  < 0.001). Independent of age, the amount of ALH CC correlated with histological degeneration of the ALH (Krenn score) ( r  = 0.55;  p  < 0.001) and the ACH (Osteoarthritis Research Society International (OARSI),  r  = 0.69;  p  < 0.001). Calcification of the ALH was characterized as calcium pyrophosphate dihydrate deposition.    Conclusion  The finding that ALH fibrocartilage is a strongly calcifying tissue is unexpected and novel. The fact that ALH calcification correlates with cartilage degeneration independent of age is suggestive of an important role of ALH calcification in osteoarthritis of the hip and renders it a potential target for the prevention and treatment of hip joint degeneration.

arthritis research and therapy

Calcification of the acetabular labrum of the hip: prevalence in the general population and relation to hip articular cartilage and fibrocartilage degeneration