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Background  We aimed to explore pressure pain sensitivity and the function of segmental and plurisegmental exercise-induced hypoalgesia (EIH) in persons with rheumatoid arthritis (RA) compared with healthy control subjects (HC).    Methods  Forty-six participants with RA (43 female, 3 male) and 20 HC (16 female, 4 male) participated in the study. Pressure pain thresholds, suprathreshold pressure pain at rest, and segmental and plurisegmental EIH during standardised submaximal contractions were assessed by algometry. Assessments of EIH were made by performing algometry alternately at the contracting (30% of the individual maximum) right  m. quadriceps  and the resting left  m. deltoideus .    Results  Participants with RA had higher sensitivity to pressure pain (RA, 318 kPa; HC, 487 kPa;  p  < 0.001), suprathreshold pressure pain 4/10 (RA, 433 kPa; HC, 638 kPa;  p  = 0.001) and suprathreshold pressure pain 7/10 (RA, 620 kPa; HC, 851 kPa;  p  = 0.002) than HC. Segmental EIH (RA, 0.99 vs 1.27;  p  < 0.001; HC, 0.89 vs 1.10;  p  = 0.016) and plurisegmental EIH (RA, 0.95 vs 1.36;  p  < 0.001; HC, 0.87 vs 1.31;  p  < 0.001) increased significantly during static muscle contraction in both groups alike ( p  > 0.05).    Conclusions  Our results indicate a generally increased pain sensitivity but normal function of EIH among persons with RA and offer one possible explanation for pain reduction observed in this group of patients following clinical exercise programmes.    Trial registration  ISRCTN registry,  ISRCTN25539102 . Retrospectively registered on 4 March 2011.

arthritis research and therapy

Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis: a substudy within the Physical Activity in Rheumatoid Arthritis 2010 study