English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We were interested in the recent publication of Albrecht et al. on body mass index (BMI) distribution in rheumatoid arthritis (RA) [1]. According to this analysis of three large cohorts, the majority of patients with RA are overweight [1]. Low remission rates and common metabolic syndrome indicate that the increasing BMI in RA should be treated, but weight loss may not be the solution as it has been linked to increased mortality [2]. Working on nutritional status in RA, we had the opportunity to compare the body composition analysis (DEXA) and physical activity levels recorded over 3 days with Actimeters (SenseWear Arm Bands, Body Media, Stanford, CA, USA) in overweight versus normalweight patients. We feel that our results may help orientate management despite the obesity paradox in RA. As depicted in Table 1, the main characteristics of the patients (age and gender) and their disease (duration, DAS28-ESR, and use of corticosteroids) were similar in the overweight and normal subjects. The rates of rheumatoid cachexia and osteopenia were dramatically reduced in overweight patients. Over the whole group, BMI were positively related to bone mass (r = +0.29, p < 0.05) and the rachis T scores (r = +0.36, p < 0.01). The overweight patients had lower levels of physical activity, and BMI was negatively related to these levels: metabolic equivalent tasks (METs) (r = –0.60, p < 0.001) and daily duration of physical activity (r = –0.41, p < 0.005). The body composition analysis of our overweight patients shows that some of their nutritional characteristics should be preserved by therapeutic intervention: less rheumatoid cachexia, that is known to reduce life expectancy, and less osteopenia, whereas the risk of fractures is doubled in RA [3]. The reduced levels of physical activity in overweight RA patients has been reported using questionnaires [4], but to our knowledge this has not yet been demonstrated with more objective actimetry measurements as we have performed. Improving these low levels of activity should be beneficial for the metabolic syndrome

High body mass index in rheumatoid arthritis: why we should promote physical activity