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Background  Illnesses transmitted by  Aedes aegypti  (Linnaeus, 1762) such as dengue, chikungunya and Zika comprise a considerable global burden; mosquito control is the primary public health tool to reduce disease transmission. Current interventions are inadequate and insecticide resistance threatens the effectiveness of these options. Dried attractive bait stations (DABS) are a novel mechanism to deliver insecticide to  Ae. aegypti . The DABS are a high-contrast 28 inch 2  surface coated with dried sugar-boric acid solution.  Aedes aegypti  are attracted to DABS by visual cues only, and the dried sugar solution elicits an ingestion response from  Ae. aegypti  landing on the surface. The study presents the development of the DABS and tests of their impact on  Ae. aegypti  mortality in the laboratory and a series of semi-field trials.    Methods  We conducted multiple series of laboratory and semi-field trials to assess the survivability of  Ae. aegypti  mosquitoes exposed to the DABS. In the laboratory experiments, we assessed the lethality, the killing mechanism, and the shelf life of the device through controlled experiments. In the semi-field trials, we released laboratory-reared female  Ae. aegypti  into experimental houses typical of peri-urban tropical communities in South America in three trial series with six replicates each. Laboratory experiments were conducted in Quito, Ecuador, and semi-field experiments were conducted in Machala, Ecuador, an area with abundant wild populations of  Ae. aegypti  and endemic arboviral transmission.    Results  In the laboratory, complete lethality was observed after 48 hours regardless of physiological status of the mosquito. The killing mechanism was determined to be through ingestion, as the boric acid disrupted the gut of the mosquito. In experimental houses, total mosquito mortality was greater in the treatment house for all series of experiments ( P  < 0.0001).    Conclusions  The DABS devices were effective at killing female  Ae. aegypti  under a variety of laboratory and semi-field conditions. DABS are a promising intervention for interdomiciliary control of  Ae. aegypti  and arboviral disease prevention.

Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control