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Malaria still has a devastating impact on public health and welfare in Cameroon. Despite the increasing number of studies conducted on disease prevalence, transmission patterns or treatment, there are to date, not enough studies summarising findings from previous works in order to identify gaps in knowledge and areas of interest where further evidence is needed to drive malaria elimination efforts. The present study seeks to address these gaps by providing a review of studies conducted so far on malaria in Cameroon since the 1940s to date. Over 250 scientific publications were consulted for this purpose. Although there has been increased scale-up of vector control interventions which significantly reduced the morbidity and mortality to malaria across the country from a prevalence of 41% of the population reporting at least one malaria case episode in 2000 to a prevalence of 24% in 2017, the situation is not yet under control. There is a high variability in disease endemicity between epidemiological settings with prevalence of  Plasmodium  parasitaemia varying from 7 to 85% in children aged 6 months to 15 years after long-lasting insecticidal nets (LLINs) scale-up. Four species of  Plasmodium  have been recorded across the country:  Plasmodium falciparum ,  P. malariae ,  P. ovale  and  P. vivax . Several primate-infecting  Plasmodium  spp. are also circulating in Cameroon. A decline of artemisinin-based combinations therapeutic efficacy from 97% in 2006 to 90% in 2016 have been reported. Several mutations in the  P. falciparum  chloroquine resistance ( Pfcrt)  and  P. falciparum  multidrug resistance 1 ( Pfmdr1 ) genes conferring resistance to either 4-amino-quinoleine, mefloquine, halofanthrine and quinine have been documented. Mutations in the  Pfdhfr  and  Pfdhps  genes involved in sulfadoxine-pyrimethamine are also on the rise. No mutation associated with artemisinin resistance has been recorded. Sixteen anopheline species contribute to malaria parasite transmission with six recognized as major vectors:  An. gambiae ,  An. coluzzii ,  An. arabiensis ,  An. funestus ,  An. nili  and  An. moucheti.  Studies conducted so far, indicated rapid expansion of DDT, pyrethroid and carbamate resistance in  An. gambiae ,  An. coluzzii ,  An. arabiensis  and  An. funestus  threatening the performance of LLINs. This review highlights the complex situation of malaria in Cameroon and the need to urgently implement and reinforce integrated control strategies in different epidemiological settings, as part of the substantial efforts to consolidate gains and advance towards malaria elimination in the country.

Review of malaria situation in Cameroon: technical viewpoint on challenges and prospects for disease elimination