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Background  An imidacloprid/flumethrin collar (Seresto®) was previously shown to prevent infection with  Babesia canis , transmitted by  Dermacentor reticulatus , in dogs for up to 1 month after application. The present study evaluated the prevention of transmission throughout the claimed efficacy period of 8 months.    Methods  Eight animals each were randomly included in groups 1 (negative control) and 2 (Seresto® collar), respectively. Animals in group 2 received the Seresto® collar on Day 0. Tick challenges were performed monthly from the 2nd to the 8th month. Assessment criteria included  in situ  tick counts 48 hours post-challenge, polymerase chain reaction (PCR) analyses and immunofluorescence assays (IFA). Whenever dogs were diagnosed with babesiosis they were “rescue-treated”, excluded and replaced. Consequently, 24 replacement animals were introduced at various time points throughout the study in the control group; thus data for a total of 32 dogs were available in the latter group at study termination.    Results  Acaricidal efficacy for  in situ  counts was 93% on Day 30, and ranged from 97 to 100% thereafter. No  B. canis  specific DNA or antibodies were detected in any Seresto®-treated dog at any time.  Babesia canis -specific DNA and antibodies were detected in 2–6 of 8 control dogs after each challenge, confirming the validity of the challenge model.    Conclusions  The Seresto® collar was highly effective against challenges with  D. reticulatus  ticks for up to 8 months. The high sustained acaricidal efficacy over this period prevented transmission of  B. canis , thus fully protecting dogs against infection in this experimental infestation model.

parasites and vectors

A study on the long-term efficacy of Seresto® collars in preventing Babesia canis (Piana &amp; Galli-Valerio, 1895) transmission to dogs by infected Dermacentor reticulatus (Fabricius, 1794) ticks