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Background   Dipylidium caninum  is a common tapeworm of dogs contracted from ingestion of fleas containing the infective cysticercoid stage. Fluralaner is a systemically distributed isoxazoline class insecticide that delivers highly effective activity against fleas and ticks for up to 12 weeks after a single oral or topical treatment. This study evaluated the impact of this flea insecticidal efficacy on the transmission of  D. caninum  to dogs.    Methods  Dogs were weighed and treated with a cestocide and then randomly assigned to 3 groups of 8. Fluralaner was administered topically (at the commercial dose) to one group and orally to another group while the third received topically administered sterile water. All dogs were subsequently infested with about 100  D .  caninum  infected  Ctenocephalides felis  at 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 77 and 83 days after treatment. Visual proglottid inspections and counts were conducted daily from 35 to 113 days post-treatment. Post-treatment  D. caninum  incidence was calculated for each group and compared between treated and untreated groups.    Results  All 8 dogs in the placebo-treated group became infected with  D .  caninum  while no shed proglottids were observed at any point during the post-treatment period from any dog in either fluralaner treated group.    Conclusions  The insecticidal efficacy of a single treatment of either orally or topically administered fluralaner prevented  D. caninum  transmission from infected fleas to susceptible dogs for up to 12 weeks following administration.

Topical or oral fluralaner efficacy against flea (Ctenocephalides felis) transmission of Dipylidium caninum infection to dogs