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Background  From 2011 to 2015, seven trachoma impact surveys in 150 districts across Amhara, Ethiopia, included in their design a nested study to estimate the zonal prevalence of intestinal parasite infections including soil-transmitted helminths (STH) and  Schistosoma mansoni .    Methods  A multi-stage cluster random sampling approach was used to achieve a population-based sample of children between the ages of 6 and 15 years. Stool samples of approximately 1 g were collected from assenting children, preserved in 10 ml of a sodium acetate-acetic acid-formalin solution, and transported to the Amhara Public Health Research Institute for processing with the ether concentration method and microscopic identification of parasites. Bivariate logistic and negative binomial regression were used to explore associations with parasite prevalence and intensity, respectively.    Results  A total of 16,955 children were selected within 768 villages covering 150 districts representing all ten zones of the Amhara region. The final sample included 15,455 children of whom 52% were female and 75% reported regularly attending school. The regional prevalence among children of 6 to 15 years of age was 36.4% (95% confidence interval, CI: 34.9–38.0%) for any STH and 6.9% (95% CI: 5.9–8.1%) for  S. mansoni.  The zonal prevalence of any STH ranged from 12.1 to 58.3%, while  S. mansoni  ranged from 0.5 to 40.1%. Categories of risk defined by World Health Organization guidelines would indicate that 107 districts (71.3%) warranted preventive chemotherapy (PC) for STH and 57 districts (38.0%) warranted PC for schistosomiasis based solely on  S. mansoni . No statistical differences in the prevalence of these parasites were observed among boys and girls, but age and school attendance were both associated with hookworm infection (prevalence odds ratio, POR: 1.02,  P  = 0.03 per 1 year, and POR: 0.81,  P  = 0.001, respectively) and age was associated with infection by any STH (POR: 1.02,  P  = 0.03). Age was also associated with reduced intensity of  Ascaris lumbricoides  infection (unadjusted rate ratio: 0.96,  P  = 0.02) and increased intensity of hookworm infection (unadjusted rate ratio: 1.07,  P  < 0.001).    Conclusions  These surveys determined that between 2011 and 2015, STH and  Schistosoma mansoni  were present throughout the region, and accordingly, these results were used to guide PC distribution to school-age children in Amhara.    Electronic supplementary material  The online version of this article (10.1186/s13071-018-3008-0) contains supplementary material, which is available to authorized users.

Prevalence of soil-transmitted helminths and Schistosoma mansoni among a population-based sample of school-age children in Amhara region, Ethiopia